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5-Amino 1MQ Peptide: Benefits & How It Works

Updated: Dec 11, 2023

Evidence-Based. Scientifically Reviewed.


  • 5-Amino 1MQ is an NNMT inhibitor

  • It promotes weight loss, muscle growth, cellular energy, and NAD+

  • It's commonly used for performance-enhancing and anti-aging, it may be effective for both


5-amino 1MQ is a small, selective molecule that can easily penetrate cell membranes.


This molecule is distinguished by its specific inhibition of the enzyme nicotinamide N-methyltransferase (NNMT), while leaving other metabolic enzymes unaffected.


This unique characteristic positions it as a potential option for numerous therapeutic uses.


In the realms of biohacking, performance-enhancing drugs (PEDs), and peptide enthusiasts, 5-amino 1MQ is well-recognized and frequently discussed.



How It Works

5-amino 1MQ (5-amino-1-methylquinolinium) works primarily by blocking NNMT (Nicotinamide N-methyltransferase), which plays a pivotal role in cellular metabolism and energy homeostasis. By inhibiting NNMT, 5-amino 1MQ can:

  • enhance fat cell metabolism

  • promote weight loss

  • stimulate the production of nicotinamide adenine dinucleotide (NAD+)

It can activate the sirtuin-1 (SIRT1) gene, also known as the "longevity gene", due to its ability to help counter various age-related diseases and processes.


Effects of 5-Amino 1MQ

This peptide has many effects and benefits, as detailed below.


infographic showing how 5-amino 1mq works

1. Combats Obesity

5-amino 1MQ has demonstrated a notable effect in decreasing body fat through the suppression of NNMT, an enzyme typically found in higher levels in the fat tissues of obese people.


By inhibiting NNMT, there's a subsequent rise in NAD+ levels, which boosts the metabolic activity of fat cells.


2. Improves Insulin Sensitivity

This peptide has shown promise in enhancing insulin sensitivity, positioning it as a potential tool in the management of type 2 diabetes and metabolic syndrome.

3. Improves Lipid Profile

5-amino 1MQ influences lipid metabolism, aiding in the reduction of triglyceride and cholesterol levels, which could help lower the risk of obesity-related cardiovascular diseases.


4. Enhances Muscle Stem Cell Activity

5-amino 1MQ boosts the growth and activity of satellite cells, which are essential muscle stem cells.


This enhancement is crucial for muscle repair and regeneration, especially significant for older adults and athletes.


Consequently, there is an increase in muscle fiber size, contributing to enhanced muscle mass and strength.



5. Reduces Muscle Wasting

5-amino 1MQ exhibits promise in addressing muscle wasting conditions like sarcopenia and cachexia.


It works by blocking pathways that contribute to muscle atrophy, often triggered by prolonged inactivity or illness, thereby aiding in the maintenance of muscle mass and strength.


This could be particularly beneficial for older adults and individuals with chronic illnesses.

6. Activates SIRT1 Longevity Gene

5-amino 1MQ, through its role in elevating NAD+ levels, activates SIRT1, a gene linked to longevity and resilience against age-related diseases.


This action may have significant effects on anti-aging, combating neurodegenerative diseases, and enhancing overall cellular health.

7. Neuroprotective Effects

Initial research indicates that 5-amino 1MQ might possess neuroprotective properties, which could be advantageous in treating conditions such as Alzheimer's disease and other types of neurodegenerative disorders.

8. Increases Cellular Energy

5-amino 1MQ, by regulating NAD+ metabolism, contributes to the balance of cellular energy. It enhances mitochondrial efficiency, a key factor for muscle endurance.


This improvement in mitochondrial function results in more effective energy use in muscle cells, enabling extended physical activity and boosting athletic performance.


Additionally, the compound may help reduce muscle fatigue by streamlining energy metabolism, which can prolong endurance during high-intensity exercises.


Consequently, this could lead to improved endurance and cardiovascular performance.

9. Potential Anti-Cancer Effects

Recent studies suggest that 5-amino 1MQ has the potential to interfere with the metabolic processes in specific types of cancer cells.



NNMT-Inhibitor Effects on Muscle Growth

5-amino 1MQ is categorized as an inhibitor of NNMT (nicotinamide N-methyltransferase).


As of now, no specific drugs are recognized for regenerating muscle stem cells, also known as satellite cells.


In a particular study, aged mice were administered varying doses of an NNMT inhibitor following a muscle injury.


This research focused on evaluating the efficacy of their muscle stem cells by monitoring cell activity and the healing of muscles.


Findings revealed that mice treated with the NNMT inhibitor exhibited enhanced activity in muscle stem cells, resulting in larger muscle fibers and stronger muscles compared to those that were not treated.


This improvement occurred irrespective of sarcopenia, the age-related decline in muscle mass, which typically diminishes the effectiveness and activation potential of muscle stem cells in response to injury.


Safety & Adverse Effects

So far, 5-amino 1MQ has shown good tolerability in conducted studies.


Yet, its long-term safety profile remains under exploration, particularly in light of its effects on different metabolic pathways.


There's also a scarcity of data regarding the safety of this research peptide in particular groups like pregnant or breastfeeding women, children, and individuals with existing health conditions.


Given these factors, caution is recommended, and the use of 5-amino 1MQ is not advised until further research is conducted.


Reported Adverse Effects

  • Sleep Issues: There are accounts of people experiencing sleep problems, possibly related to the metabolic alterations caused by 5-amino 1MQ.

  • Low Blood Sugar: Instances of hypoglycemia, or low blood sugar levels, have been reported, which might be a consequence of using this peptide.

  • Gastrointestinal Issues: In certain cases, mild digestive discomfort has been observed.


Not Approved

Currently, 5-amino 1MQ has not received approval from the FDA or any other health regulatory body for any particular medical condition, and its usage remains largely experimental.



References

  1. Neelakantan H, Vance V, Wetzel MD, Wang HL, McHardy SF, Finnerty CC, Hommel JD, Watowich SJ. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochem Pharmacol. 2018 Jan;147:141-152. doi: 10.1016/j.bcp.2017.11.007. Epub 2017 Nov 15. PMID: 29155147; PMCID: PMC5826726.

  2. Liu JR, Deng ZH, Zhu XJ, Zeng YR, Guan XX, Li JH. Roles of Nicotinamide N-Methyltransferase in Obesity and Type 2 Diabetes. Biomed Res Int. 2021 Jul 27;2021:9924314. doi: 10.1155/2021/9924314. PMID: 34368359; PMCID: PMC8337113.

  3. Li XY, Pi YN, Chen Y, Zhu Q, Xia BR. Nicotinamide N-Methyltransferase: A Promising Biomarker and Target for Human Cancer Therapy. Front Oncol. 2022 Jun 9;12:894744. doi: 10.3389/fonc.2022.894744. PMID: 35756670; PMCID: PMC9218565.

  4. Neelakantan H, Brightwell CR, Graber TG, Maroto R, Wang HL, McHardy SF, Papaconstantinou J, Fry CS, Watowich SJ. Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. Biochem Pharmacol. 2019 May;163:481-492. doi: 10.1016/j.bcp.2019.02.008. Epub 2019 Feb 10. PMID: 30753815; PMCID: PMC6469996.

  5. Neelakantan H, Vance V, Wang HL, McHardy SF, Watowich SJ. Noncoupled Fluorescent Assay for Direct Real-Time Monitoring of Nicotinamide N-Methyltransferase Activity. Biochemistry. 2017 Feb 14;56(6):824-832. doi: 10.1021/acs.biochem.6b01215. Epub 2017 Jan 30. PMID: 28121423.

  6. Kannt, A., Rajagopal, S., Kadnur, S.V. et al. A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders. Sci Rep 8, 3660 (2018). https://doi.org/10.1038/s41598-018-22081-7

  7. Jang YC, Sinha M, Cerletti M, Dall'Osso C, Wagers AJ. Skeletal muscle stem cells: effects of aging and metabolism on muscle regenerative function. Cold Spring Harb Symp Quant Biol. 2011;76:101-11. doi: 10.1101/sqb.2011.76.010652. Epub 2011 Sep 29. PMID: 21960527.



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