Updated: Aug 10
Dimethylnandrolone Undecanoate (DMAU), Trestolone (MENT), and 11-methyl-19-nortestosterone (11-MNT) are sister chemicals being studied as a male contraceptive pill and as testosterone replacement.
Dimethandrolone (DMA), also known by its assigned code name CDB-1321 or as DMAU in its undecanoate esterified form, is an investigational progestogen and androgenic anabolic steroid (AAS) that is being researched for possible therapeutic application.
DMAU is in development as a male contraceptive.
2019 Phase I human clinical studies were successful and it was deemed non-toxic and well-tolerated.
After cessation, spermatogenesis returns quickly.
Can be orally-administered or given as injection.
Does not have aromatase action.
DMAU is 136 times more myotrophic than testosterone. It is anabolic than its sister chemicals trestolone (MENT) and 11β-methyl-19-nortestosterone (11β-MNT).
DMAU as a Male Contraceptive
Despite having low circulating testosterone levels, only a small number of participants showed symptoms associated with either excess or insufficiency of testosterone.
Eighty-two participants attended the trial. There were no significant negative outcomes. Safety laboratory measurements did not alter in a clinically relevant way. (5)
According to all of the data collected, androgen replacement with DMAU or 11-MNTDC in Cx rats led to beneficial alterations in body composition.
The maintenance of done mineral density that was equivalent to that of testosterone. (6)
Does Not 5α-Reductase
The function of 5-reduction in the androgenic activity of DMA and MNT was investigated since 5-reduced androgens, such as DHT, may increase the risk of benign prostate hyperplasia, hasten the development of prostate cancer, and increase male pattern baldness and acne. (7)
According to the findings, inhibiting the activity of 5-reductase in vivo has no effect on the androgenic efficacy of DMA, MNT, or MENT. (7)
Does Not Seem to Aromatase
The likelihood of consumers experiencing oestrogenic adverse effects is zero, claim experts at the US-based Bioqual. Dimethandrolone did not convert into oestrogenic substances during tests in test tubes. (8)
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This evidence-based analysis of Dimethylnandrolone Undecanoate (DMAU) features 8 references, listed below.
1. Attardi BJ, Hild SA, Reel JR. Dimethandrolone undecanoate: a new potent orally active androgen with progestational activity. Endocrinology. (2006)
2. Walton, Melanie J., et al. 7α-methyl-19-nortestosterone (MENT) vs Testosterone in Combination With Etonogestrel Implants for Spermatogenic Suppression in Healthy Men. Journal of Andrology. (2007)
3. Kumar N, Suvisaari J, Tsong YY, et al. Pharmacokinetics of 7 alpha-methyl-19-nortestosterone in men and cynomolgus monkeys. J Androl. (1997)
5. Thirumalai A, Ceponis J, Amory JK, et al. Effects of 28 Days of Oral Dimethandrolone Undecanoate in Healthy Men: A Prototype Male Pill. J Clin Endocrinol Metab. (2019) (Clinical Trial)
6. Attardi BJ, Marck BT, Matsumoto AM, Koduri S, Hild SA. Long-term effects of dimethandrolone 17β-undecanoate and 11β-methyl-19-nortestosterone 17β-dodecylcarbonate on body composition, bone mineral density, serum gonadotropins, and androgenic/anabolic activity in castrated male rats. J Androl. (2011)
7. Attardi BJ, Hild SA, Koduri S, et al. The potent synthetic androgens, dimethandrolone (7α,11β-dimethyl-19-nortestosterone) and 11β-methyl-19-nortestosterone, do not require 5α-reduction to exert their maximal androgenic effects. J Steroid Biochem Mol Biol. (2010)
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We strictly do not advise anyone to use, or consider using, any exogenous hormone or chemical such as trestolone, unless advised or prescribed to do so by a qualified doctor. Doing so could result in serious and long-term adverse effects.