Dimethylnandrolone (DMA) 136× More Myotrophic Than Testosterone & Novel Male Contraceptive

✔ Evidence-Based. Scientifically Reviewed by Michael Sharpe, MSc and Dr. Michael Tamber, MD.

Dimethylnandrolone Undecanoate (DMAU), Trestolone (MENT), and 11-methyl-19-nortestosterone (11-MNT) are sister chemicals being studied as a male contraceptive pill and as testosterone replacement.

Dimethandrolone (DMA), also known by its assigned code name CDB-1321 or as DMAU in its undecanoate esterified form, is an investigational progestogen and androgenic anabolic steroid (AAS) that is being researched for possible therapeutic application.

In comparison to trestolone, DMAU is a superior choice for hormone replacement, according to researchers. Trestolone has a very short half life. (1, 2, 3)

In addition, DMAU limits sperm production but does not lower libido or interfere with ejaculation, according to results from previous studies. (2, 3)

• DMAU is in development as a male contraceptive.

• 2019 Phase I human clinical studies were successful and it was deemed non-toxic and well-tolerated.

• After cessation, spermatogenesis returns quickly.

• Can be orally-administered or given as injection.

• Does not have aromatase action.

• DMAU is 136 times more myotrophic than testosterone. It is anabolic than its sister chemicals trestolone (MENT) and 11β-methyl-19-nortestosterone (11β-MNT).

DMAU as a Male Contraceptive

At the maximum studied dose of DMAU, 400 mg, individuals had marked reduction of levels of the sperm-producing hormones LH, FSH, and testosterone. (4)

Despite having low circulating testosterone levels, only a small number of participants showed symptoms associated with either excess or insufficiency of testosterone.

Studies

Eighty-two participants attended the trial. There were no significant negative outcomes. Safety laboratory measurements did not alter in a clinically relevant way. (5)

Daily oral administration of DMAU for 28 days in healthy men is well tolerated. Doses of ≥200 mg significantly suppressed serum testosterone, LH, and FSH. (5)

Androgen Replacement

According to all of the data collected, androgen replacement with DMAU or 11-MNTDC in Cx rats led to beneficial alterations in body composition.

The maintenance of done mineral density that was equivalent to that of testosterone. (6)

Does Not 5α-Reductase

DMAU is not susceptible to metabolism by the 5-reductase enzyme. (7)

The function of 5-reduction in the androgenic activity of DMA and MNT was investigated since 5-reduced androgens, such as DHT, may increase the risk of benign prostate hyperplasia, hasten the development of prostate cancer, and increase male pattern baldness and acne. (7)

According to the findings, inhibiting the activity of 5-reductase in vivo has no effect on the androgenic efficacy of DMA, MNT, or MENT. (7)

Does Not Seem to Aromatase

The likelihood of consumers experiencing oestrogenic adverse effects is zero, claim experts at the US-based Bioqual. Dimethandrolone did not convert into oestrogenic substances during tests in test tubes. (8)

References

This section contains links to research, studies, and sources of information for this article, as well as authors, contributors, etc. All sources, along with the article and facts, are subjected to a series of quality, reliability, and relevance checks.

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This evidence-based analysis of Dimethylnandrolone Undecanoate (DMAU) features 8 references, listed below.

1. Attardi BJ, Hild SA, Reel JR. Dimethandrolone undecanoate: a new potent orally active androgen with progestational activity. Endocrinology. (2006)

2. Walton, Melanie J., et al. 7α-methyl-19-nortestosterone (MENT) vs Testosterone in Combination With Etonogestrel Implants for Spermatogenic Suppression in Healthy Men. Journal of Andrology. (2007)

3. Kumar N, Suvisaari J, Tsong YY, et al. Pharmacokinetics of 7 alpha-methyl-19-nortestosterone in men and cynomolgus monkeys. J Androl. (1997)

4. Dimethandrolone Undecanoate Shows Promise as a Male Birth Control Pill

5. Thirumalai A, Ceponis J, Amory JK, et al. Effects of 28 Days of Oral Dimethandrolone Undecanoate in Healthy Men: A Prototype Male Pill. J Clin Endocrinol Metab. (2019) (Clinical Trial)

6. Attardi BJ, Marck BT, Matsumoto AM, Koduri S, Hild SA. Long-term effects of dimethandrolone 17β-undecanoate and 11β-methyl-19-nortestosterone 17β-dodecylcarbonate on body composition, bone mineral density, serum gonadotropins, and androgenic/anabolic activity in castrated male rats. J Androl. (2011)

7. Attardi BJ, Hild SA, Koduri S, et al. The potent synthetic androgens, dimethandrolone (7α,11β-dimethyl-19-nortestosterone) and 11β-methyl-19-nortestosterone, do not require 5α-reduction to exert their maximal androgenic effects. J Steroid Biochem Mol Biol. (2010)

8. Monster anabolic dimethandrolone does not aromatize

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We strictly do not advise anyone to use, or consider using, any exogenous hormone or chemical such as trestolone, unless advised or prescribed to do so by a qualified doctor. Doing so could result in serious and long-term adverse effects.