Creatine - What Is Creatine & How Does It Work? [Ultimate Guide]

Updated: Jan 24

What is creatine and how does it work?

Creatine is one of the most popular supplements in the fitness and bodybuilding community.

It increases the capacity and production of ATP, the body's primary energy source.

This post explains all there is to know about creatine.

Click the topics below or scroll down.

This post covers the following topics:

The studies done on creatine show that this supplement can increase strength, muscle mass and can also improve exercise performance, such as endurance and power. (Source)

It is also the worlds most studied supplement and has an excellent safety record. (Source)

A review conducted of the most popular supplements came to the conclusion that creatine was the most beneficial dietary supplement.

Further Reading: Top 3 Best Bodybuilding Supplements

What Is Creatine

Creatine is a compound that is actually found naturally within cells in your body.

It is found in higher concentrations in your muscle cells - around 95% of creatine is found in your muscles and the other 5% is found in the brain, liver and kidneys. (Source)

It is actually very similar to amino acids, your body can also produce creatine from the amino acids; glycine and arginine.

Taking this supplement is very popular among fitness enthusiasts, bodybuilders and other athletes.

When you supplement with creatine, your bodily stores of phosphocreatine will increase.

Phosphocreatine is a form of stored energy which helps create your body's main energy source, called ATP.

When your body has more ATP, you can perform better.

Your bodies natural production of creatine is influenced by various factors, including: (Source)

  • Dietary meat intake.

  • Level of exercise.

  • Amount of muscle mass.

  • Levels of hormones like Testosterone & IGF-1.

There are several other processes that happen while taking creatine, which can also lead to increased muscle mass and strength.

Further Reading: Is Beta-Alanine The Best Pre Workout Supplement?

How Does Creatine Work

Creatine has many effects in the body.

In high intensity exercise, creatine's main role in improving exercise performance is to increase phosphocreatine stores.

These additional phosphocreatine stores can be used to produce more energy in the form of ATP, which is the primary energy used in high intensity and high resistance exercises.

Creatine also helps you gain muscle by:

  • Increasing workload

  • Increasing anabolic hormones

  • Improving cell signalling

  • Increasing cell hydration

  • Reducing myostatin

  • Reducing protein breakdown

Below is a breakdown of each of these mechanisms.

Increasing Workload:

Creatine enables more total workload and total volume in training sessions - this promotes long-term muscle growth. (Source)

Increasing Anabolic Hormones:

Creatine can also increase the levels of certain anabolic hormones, such as IGF-1. (Source)

Improving Cell Signalling:

Satellite cell signalling is increased with the supplementation of creatine - this is a factor in muscle growth and repair. (Source)

Increasing Cell Hydration:

Creatine will increase cellular water content within the muscles, this is known as cellular volumization and many have a hypertrophic effect (making the cell bigger). (Source)

Reducing Myostatin:

Myostatin levels can be reduced with the supplementation of creatine. Myostatin is a catabolic hormone, meaning it can break down muscle tissue or limit muscle growth. (Source)

Reducing Protein Breakdown:

Creatine may also promote muscle gain by reducing protein breakdown. (Source)


There are other effects, such as an increase in phosphocreatine levels within the brain.

This can improve brain health and may even help prevent neurological disease. (Source, Source)

In summary; creatine can help provide the body and muscles with increased energy and also improve energy production.

Further Reading: How Much Water To Drink With Creatine

Top 3 Benefits Of Creatine

Creatine has a fairly large list of benefits.

Below is a curated list of our top three benefits of creatine.

  1. Increased Strength & Performance

  2. Increased Muscle Mass

  3. Improved Brain Health

1) Increased Strength & Performance

Creatine has also been shown to significantly improve strength and exercise performance.

In fact, one study has shown that adding creatine to a resistance training program improved strength by around 8%, weightlifting performance by around 14% and increased bench press one-rep max by up to 43%. (Source)

This supplement can help to maintain strength and exercise performance while also increasing muscle mass during over-training.

In another study; 28 days of supplementing creatine increased bike-sprinting performance in well-trained athletes by 15% and improved bench-press performance by 6%. (Source)

These improvements in strength and performance are mainly caused by your body’s increased capacity to produce energy, called ATP.

ATP usually becomes depleted after around 8-10 seconds of high intensity exercise - because creatine helps you produce and store more energy, you can increase this capacity by a few seconds.

Further Reading: Creatine Increases Strength & Performance

2) Increased Muscle Mass

Creatine has shown to be useful in increasing long-term, as well as short-term, muscle growth. (Source)

It has also been chosen as the number one most beneficial dietary supplement. (Source)

In one 14-week study done on older adults found that adding creatine to a resistance training program significantly increased muscle mass and leg strength. (Source)

In another 12-week study examining already trained individuals, creatine was able to increase muscle fibre growth over 2x more than training without supplementation. (Source)

In these studies; taking creatine led to increased fat-free mass, physical performance and enhanced muscle morphology in response to resistance training, possibly mediated by higher quality training sessions.

In conclusion; creatine is able to enhance muscle growth, strength and performance in trained and untrained individuals.

Further Reading: Creatine Increases Muscle Growth

3) Improved Brain Health

Creatine may also be of help in those with neurological disease, it may ease symptoms and slow the progression, although more research is needed to conclude anything.

Like muscle tissue, your brain also stores phosphocreatine and needs ATP for optimal functioning.

Even though there may be potential benefits of creatine for treating or preventing neurological disease, most of the research so far has been performed with animals.

However, creatine supplementation may help in those with: (Source, Source, Source & Others)

  • Parkinson’s Disease

  • Alzheimer’s Disease

  • Huntington’s Disease

  • Epilepsy

  • Brain/Spinal Cord Injuries

  • Motor Neuron Disease

  • Ischemic Stroke

  • Cognitive Decline

Despite the fact most research is with animals, there still has been human research conducted.

A six-month study on children who experienced traumatic brain injury have observed a 70% reduction in fatigue and a 50% reduction in dizziness with creatine supplementation. (Source)

Human research suggests that it can also aid the elderly and those at risk of neurological diseases. (Source)

Another interesting fact is vegetarians actually have less phosphocreatine stores due to less, or no meat intake and therefore respond very well to creatine supplementation. (Source)

Further Reading: Creatine Improves Brain Health

Other Benefits Of Creatine:

Creatine may have many other benefits too.

Although more research is needed, there is preliminary research that suggests creatine may:

  • Help in treating non-alcoholic fatty liver disease.

  • Help improve general brain function.

  • Help lower blood sugar levels and fight diabetes.

  • Help in reducing tiredness and fatigue.

  • Help in improving quality of life and muscle function in older people.

Further Reading: Creatine's Benefits

Side Effects Of Creatine

Creatine has an excellent safety profile.

It is one of the most well researched dietary supplements.

Does Creatine Cause Dehydration & Cramps?

Some people claim that creatine can cause dehydration and cramps, however, research doesn’t support this claim.

In fact, studies suggest that it can actually reduce the incidence of cramps and dehydration during high intensity endurance exercise in high temperatures. (Source)

Does Creatine Cause Baldness?

Another claim is that creatine can cause baldness, this is mostly based on anecdotal reports - however, a small study in 2009 did find around a 40% increase in DHT levels following supplementation. (Source)

DHT is a hormone responsible for promoting baldness - therefore it is theoretically possible that creatine could promote the rate of hair loss.

However, this is not proven.

Further Reading: Does Creatine Cause Baldness?

Other Side Effects:

However, studies lasting up to 4 years on the long-term safety of creatine have found no adverse effects. (Source)

There is also no evidence that it can harm the liver or kidneys in healthy people who take normal doses. (Source)

However, those with pre-existing liver or kidney issues should consult a qualified doctor before supplementing with creatine, or avoid supplementing with it altogether.

One of the most comprehensive studies conducted on creatine measured 52 different blood markers and observed no negative effects following 21 months of supplementation.

Overall, creatine seems to be extremely safe, well researched and has essentially no proven adverse effects.

Further Reading: Creatine Side Effects

The Different Types Of Creatine

There are multiple types of creatine.

The top three are:

  1. Creatine Monohydrate

  2. Creatine Ethyl Ester

  3. Creatine Hydrochloride

Further Reading: Types Of Creatine

1) Creatine Monohydrate

Creatine monohydrate is the most common, cheapest and most widely available form of creatine.

It is the form used with most research and studies.

This means that most of creatine’s beneficial effects, such as; improved strength, muscle gain and endurance, have been seen almost exclusively when the monohydrate form was used.

Creatine monohydrate is made up of a creatine molecule and a water molecule, it can also be processed in a few ways. Such as when the water molecule is removed, resulting in another type called creatine anhydrous.

The removal of this water molecule increases the amount of creatine in each dose - the anhydrous type is 100% creatine by weight, whereas monohydrate is around 90% creatine by weight.

It can also be micronized or mechanically processed in order to improve water solubility.

In theory, better water solubility could improve your body’s ability to absorb it - however, this isn't proven.

2) Creatine Ethyl Ester

Creatine ethyl ester is another common type of creatine.

Some manufacturers claim that the ethyl ester form is better than the other forms of creatine.

Some evidence indicates it may be better absorbed than creatine monohydrate in the body. (Source)

Due to differences in muscle uptake rates, some believe that the ethyl ester form could outperform creatine monohydrate.

However, one study directly comparing the two types of creatine found that it was worse at increasing phosphocreatine content in the blood and in the muscles. (Source)

Because of this, using creatine ethyl ester is not recommended.

3) Creatine Hydrochloride

Creatine hydrochloride is another type of creatine that has gained popularity with some manufacturers and users.

It's thought to have superior water solubility - because of its superior solubility in water, it’s speculated that a lower dose can be used.

However, this is only theory until it's proven.

One study found that creatine hydrochloride was 38 times more soluble than the monohydrate form. (Source)

However, there are no published studies on creatine hydrochloride usage in humans.

Given the large amount of studies supporting the effectiveness of creatine monohydrate, the hydrochloride form can’t be recommended until more data is published.

Creatine Dosage

Most people who use creatine go on a process called "loading" and "maintenance", or some just take the same amount each day.

Absorption may be also improved slightly by taking creatine alongside a carb or protein based meal due to the release of insulin. (Source)

Both ways are fine and safe, however, to get the quickest increase in phosphocreatine stores, loading is the better option.

To load with creatine, take 15-20 grams creatine per day for 5-7 days. This should be split into three or four 5 gram servings per day.

After this loading period, take 3-5 grams per day to maintain these higher levels of phosphocreatine within your muscles. There is no benefit to cycling creatine, so stay on this dosage for as long as you want.

If you choose not to do the loading phase, you can simply take 3-5 grams per day.

However, it may take 3-4 weeks to maximize your phosphocreatine stores.

Since creatine has a volumizing effect and pulls water into your muscle cells, it is advised to take it with a larger glass of water and keep well hydrated throughout the day.

Summary Of Creatine

Creatine is one of the safest, most well researched and beneficial dietary supplements you can take.

Supplementation can support quality of life in older adults, improves brain health and increases endurance, strength and muscle growth.

The most recommended type of creatine is creatine monohydrate, it is the most researched and has proven benefits.

Older people, vegetarians and those with busy lives may find it useful to supplement with creatine.

Further Reading:

-> Is Creatine Bad For You? (Top 3 Myths Debunked)

-> How Much Water Should You Drink With Creatine

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